Antioxidants (Aug 2020)

The Impact of Formulation on Lutein, Zeaxanthin, and <i>meso</i>-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study

  • Marina Green-Gomez,
  • Alfonso Prado-Cabrero,
  • Rachel Moran,
  • Tommy Power,
  • Laura G. Gómez-Mascaraque,
  • Jim Stack,
  • John M. Nolan

DOI
https://doi.org/10.3390/antiox9080767
Journal volume & issue
Vol. 9, no. 8
p. 767

Abstract

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Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561).

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