Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

Céline Souilhol; Christèle Gonneau; Javier G. Lendinez; Antoniana Batsivari; Stanislav Rybtsov; Heather Wilson; Lucia Morgado-Palacin; David Hills; Samir Taoudi; Jennifer Antonchuk; Suling Zhao; Alexander Medvinsky

doi:10.1038/ncomms10784

Nature Communications (Mar 2016)

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

Céline Souilhol,
Christèle Gonneau,
Javier G. Lendinez,
Antoniana Batsivari,
Stanislav Rybtsov,
Heather Wilson,
Lucia Morgado-Palacin,
David Hills,
Samir Taoudi,
Jennifer Antonchuk,
Suling Zhao,
Alexander Medvinsky

Affiliations

Céline Souilhol: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Christèle Gonneau: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Javier G. Lendinez: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Antoniana Batsivari: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Stanislav Rybtsov: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Heather Wilson: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Lucia Morgado-Palacin: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
David Hills: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Samir Taoudi: Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research
Jennifer Antonchuk: STEMCELL Technologies Inc., Vancouver
Suling Zhao: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter
Alexander Medvinsky: Institute for Stem Cell Research, Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, SCRM Bioquarter

DOI: https://doi.org/10.1038/ncomms10784
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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It is unclear how the microenvironment of the aorta-gonad-mesonephros influences haematopoietic stem cell (HSC) production early in mouse development. Here, Souilhol et al. use an in vitroaggregate system as a tool to understand how several pathways, BMP, SCF and Shh, may regulate HSC production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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