Study on the effect of photostimulation in the methotrexate therapy of Walker 256 tumour

Abstract

The aim of this study is to highlight the favorable effect of photostimulation obtained in the methotrexate therapy on Walker 256 tumour. The method of selective tumour photostimulation follows the increase, in the malignant tissue, of the concentration of any specific substance for the neoplastic cell that can be administered "in bolus" for cytostatic treatment. This goal is achieved by exposing the tumour tissue to the optical field emitted by a specially designed equipment. On the other hand, in the case of chemotherapy, there are certain types of cytostatics that have a "positive photodynamic potential", thus, following the interaction between their molecules and the light radiation with the strictly determined parameters, free radicals are born that destroy the intracellular cytostatic fixation targets. This phenomenon is called the photodynamic activation of the cytostatic, the method is called Photostimulated Chemotherapy (PSChT), and the drug used in this study is Methotrexate (MTX).

Keywords

• experimental model
• rat
• methotrexate
• photostimulation
• walker 256 tumour