Highly structured homolog pairing reflects functional organization of the Drosophila genome

Jumana AlHaj Abed; Jelena Erceg; Anton Goloborodko; Son C. Nguyen; Ruth B. McCole; Wren Saylor; Geoffrey Fudenberg; Bryan R. Lajoie; Job Dekker; Leonid A. Mirny; C.-ting Wu

doi:10.1038/s41467-019-12208-3

Nature Communications (Oct 2019)

Highly structured homolog pairing reflects functional organization of the Drosophila genome

Jumana AlHaj Abed,
Jelena Erceg,
Anton Goloborodko,
Son C. Nguyen,
Ruth B. McCole,
Wren Saylor,
Geoffrey Fudenberg,
Bryan R. Lajoie,
Job Dekker,
Leonid A. Mirny,
C.-ting Wu

Affiliations

Jumana AlHaj Abed: Department of Genetics, Harvard Medical School
Jelena Erceg: Department of Genetics, Harvard Medical School
Anton Goloborodko: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
Son C. Nguyen: Department of Genetics, Harvard Medical School
Ruth B. McCole: Department of Genetics, Harvard Medical School
Wren Saylor: Department of Genetics, Harvard Medical School
Geoffrey Fudenberg: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
Bryan R. Lajoie: Howard Hughes Medical Institute and Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Job Dekker: Howard Hughes Medical Institute and Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Leonid A. Mirny: Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
C.-ting Wu: Department of Genetics, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-12208-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and functional roles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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