Clinical Interventions in Aging (Jul 2023)

Carbapenem-Resistant Klebsiella pneumoniae Infection and Its Risk Factors in Older Adult Patients

  • Çölkesen F,
  • Tarakçı A,
  • Eroğlu E,
  • Kacar F,
  • Özdemir Armağan Ş,
  • Can S,
  • Erol B,
  • Aksay O,
  • Çölkesen F

Journal volume & issue
Vol. Volume 18
pp. 1037 – 1045

Abstract

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Fatma Çölkesen,1 Arzu Tarakçı,2 Esma Eroğlu,3 Fatma Kacar,4 Şule Özdemir Armağan,2 Selver Can,5 Bağdat Erol,6 Oyagül Aksay,6 Fatih Çölkesen7 1Department of Infectious Diseases and Clinical Microbiology, Konya Numune Hospital, Konya, Turkey; 2Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Konya City Hospital, Konya, Turkey; 3Department of Infectious Diseases and Clinical Microbiology, Meram State Hospital, Konya, Turkey; 4Department of Infectious Diseases and Clinical Microbiology, Medova Hospital, Konya, Turkey; 5Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Beyhekim Training and Research Hospital, Konya, Turkey; 6Infection Control Committee, University of Health Sciences, Konya City Hospital, Konya, Turkey; 7Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, TurkeyCorrespondence: Fatih Çölkesen, Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey, Tel +903322354500, Fax +903322356786, Email [email protected]: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has recently gained worldwide interest due to limited treatment options and high morbidity and mortality rates. The aim of this study was to determine the risk factors of carbapenem-resistant K. pneumoniae (CRKP) infection in older adult patients.Material and Methods: This retrospective, single-center study included 132 patients with healthcare-associated CRKP infection (case group) and 150 patients with healthcare-associated carbapenem-susceptible K. pneumoniae (CSKP) infection (control group), aged > 65 years.Results: In the CRKP and CSKP groups, 79 (59.8%) and 80 (53.3%) patients were males, and the mean ages were 77.8 ± 7.8 and 76.6 ± 7.7 years, respectively. Diabetes mellitus (DM), malignancy, cardiovascular diseases (CVDs), surgical intervention, invasive mechanical ventilation, central venous catheter insertion, parenteral nutrition, hospitalization in the previous 6 months, antibiotic use in the previous 3 months, and exposure to cephalosporins, fluoroquinolones, and carbapenems were significantly more common in the CRKP than the CSKP group (all p < 0.05). The multivariate logistic regression analysis identified malignancy, CVDs, DM, invasive mechanical ventilation, hospitalization in the previous 6 months, ICU admission, and exposure to cephalosporins, quinolones, and carbapenems as independent risk factors for CRKP infection in older adult patients.Conclusion: DM, malignancy, CVDs, ICU admission, invasive mechanical ventilation, and exposure to ceftriaxone, fluoroquinolones, and carbapenems were independent risk factors for CRKP infection in older adult patients. The identification of risk factors for CRKP infection can help to prevent and treat CRKP infection.Keywords: older adult patients, infection, carbapenem, Klebsiella pneumoniae, resistance

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