Nature Communications (Mar 2020)
Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
- Qingjian Li,
- Tao Qin,
- Zhuofei Bi,
- Huangming Hong,
- Lin Ding,
- Jiewen Chen,
- Wei Wu,
- Xiaorong Lin,
- Wenkui Fu,
- Fang Zheng,
- Yandan Yao,
- Man-Li Luo,
- Phei Er Saw,
- Gerburg M. Wulf,
- Xiaoding Xu,
- Erwei Song,
- Herui Yao,
- Hai Hu
Affiliations
- Qingjian Li
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Tao Qin
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Zhuofei Bi
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Huangming Hong
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Lin Ding
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Jiewen Chen
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Wei Wu
- Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Xiaorong Lin
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Wenkui Fu
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Fang Zheng
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Yandan Yao
- Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Man-Li Luo
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Phei Er Saw
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Gerburg M. Wulf
- Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School
- Xiaoding Xu
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Erwei Song
- Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Herui Yao
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Hai Hu
- Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- DOI
- https://doi.org/10.1038/s41467-020-15308-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistant breast cancer PDXs to NAC.
