Frontiers in Chemistry (Dec 2022)

Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates

  • Yonggang Jiang,
  • Bijun Wang,
  • Dongxiang Liu,
  • Dazhen Xia,
  • Zhengfen Liu,
  • Liang Li,
  • Guogang Deng,
  • Xiaodong Yang

DOI
https://doi.org/10.3389/fchem.2022.1091566
Journal volume & issue
Vol. 10

Abstract

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Aryl acrylonitriles are an important subclass of acrylonitriles in the medicinal chemistry and pharmaceutical industry. Herein, an efficient synthesis of aryl acrylonitrile derivatives using a Palladium/NIXANTPHOS-based catalyst system was developed. This approach furnishes a variety of substituted and functionalized aryl acrylonitriles (up to 95% yield). The scalability of the transformation and the synthetic versatility of aryl acrylonitrile were demonstrated.

Keywords