Total Synthesis of Cyclopiamide A Using Palladium-Catalyzed Domino Cyclization

Abstract

Total synthesis of cyclopiamide A was accomplished using a palladium-catalyzed domino cyclization. Three rings in the tetracyclic skeleton of cyclopiamide A were constructed in a one-step domino reaction incorporating double carbopalladation and C-H activation.

Keywords

• cyclopiamide A
• domino reaction
• palladium-catalyzed
• carbopalladation
• C-H activation