Nature Communications (Jun 2022)

Taf2 mediates DNA binding of Taf14

  • Brianna J. Klein,
  • Jordan T. Feigerle,
  • Jibo Zhang,
  • Christopher C. Ebmeier,
  • Lixin Fan,
  • Rohit K. Singh,
  • Wesley W. Wang,
  • Lauren R. Schmitt,
  • Thomas Lee,
  • Kirk C. Hansen,
  • Wenshe R. Liu,
  • Yun-Xing Wang,
  • Brian D. Strahl,
  • P. Anthony Weil,
  • Tatiana G. Kutateladze

DOI
https://doi.org/10.1038/s41467-022-30937-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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Here the authors report that the Taf2 and Taf14 subunits of the yeast TFIID complex interact and mediate binding to chromatin. Binding of Taf2 to Taf14 promotes a conformational rearrangement in Taf14, resulting in a release of the linker region for the engagement with the nucleosome and their association with DNA is essential for transcriptional regulation.