Nature Communications (Jan 2023)

Biomolecular condensates formed by designer minimalistic peptides

  • Avigail Baruch Leshem,
  • Sian Sloan-Dennison,
  • Tlalit Massarano,
  • Shavit Ben-David,
  • Duncan Graham,
  • Karen Faulds,
  • Hugo E. Gottlieb,
  • Jordan H. Chill,
  • Ayala Lampel

DOI
https://doi.org/10.1038/s41467-023-36060-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 11

Abstract

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The molecular mechanisms underlying the formation of biomolecular condensates have not been fully elucidated. Here the authors show that the LLPS propensity, dynamics, and encapsulation efficiency of designed peptide condensates can be tuned by subtle changes to the peptide composition.