Medical Review (Aug 2024)
Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications
- Zhao Jinyu,
- Yue Ping,
- Mi Ningning,
- Li Matu,
- Fu Wenkang,
- Zhang Xianzhuo,
- Gao Long,
- Bai Mingzhen,
- Tian Liang,
- Jiang Ningzu,
- Lu Yawen,
- Ma Haidong,
- Dong Chunlu,
- Zhang Yong,
- Zhang Hengwei,
- Zhang Jinduo,
- Ren Yanxian,
- Suzuki Azumi,
- Wong Peng F.,
- Tanaka Kiyohito,
- Rerknimitr Rungsun,
- Junger Henrik H.,
- Cheung Tan T.,
- Melloul Emmanuel,
- Demartines Nicolas,
- Leung Joseph W.,
- Yao Jia,
- Yuan Jinqiu,
- Lin Yanyan,
- Schlitt Hans J.,
- Meng Wenbo
Affiliations
- Zhao Jinyu
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Yue Ping
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Mi Ningning
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Li Matu
- Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Fu Wenkang
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Zhang Xianzhuo
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Gao Long
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Bai Mingzhen
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Tian Liang
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Jiang Ningzu
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Lu Yawen
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Ma Haidong
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Dong Chunlu
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Zhang Yong
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Zhang Hengwei
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Zhang Jinduo
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Ren Yanxian
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Suzuki Azumi
- Department of Gastroenterology, Hamamatsu Medical Center, Hamamatsu, Japan
- Wong Peng F.
- Department of Vascular Surgery, The James Cook University Hospital, Middlesbrough, UK
- Tanaka Kiyohito
- Department of Gastroenterology, Kyoto Second Red Cross Hospital, Kyoto, Japan
- Rerknimitr Rungsun
- Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
- Junger Henrik H.
- Department of Surgery, University Medical Center Regensburg, Regensburg, Germany
- Cheung Tan T.
- Department of Surgery, The University of Hong Kong, Hong Kong, China
- Melloul Emmanuel
- Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, Switzerland
- Demartines Nicolas
- Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, Switzerland
- Leung Joseph W.
- Division of Gastroenterology and Hepatology, UC Davis Medical Center and Sacramento VA Medical Center, Sacramento, CA, USA
- Yao Jia
- The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China
- Yuan Jinqiu
- Clinical Research Center, Big Data Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
- Lin Yanyan
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- Schlitt Hans J.
- Department of Surgery, University Medical Center Regensburg, Regensburg, Germany
- Meng Wenbo
- Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
- DOI
- https://doi.org/10.1515/mr-2024-0029
- Journal volume & issue
-
Vol. 4,
no. 4
pp. 326 – 365
Abstract
Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality. Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders, which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries. Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases. In this review, we emphasized the importance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations, epidemiology, and aberrant cellular composition involving the biliary ductules, cholangiocytes, immune system, fibroblasts, and the microbiome. We also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related cholangiopathies. This review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.
Keywords
