Hepatology Communications (Nov 2018)
Gamma Glutamyltransferase Reduction Is Associated With Favorable Outcomes in Pediatric Primary Sclerosing Cholangitis
- Mark R. Deneau,
- Cara Mack,
- Reham Abdou,
- Mansi Amin,
- Achiya Amir,
- Marcus Auth,
- Fateh Bazerbachi,
- Anne Marie Broderick,
- Albert Chan,
- Matthew DiGuglielmo,
- Wael El‐Matary,
- Mounif El‐Youssef,
- Federica Ferrari,
- Katryn N. Furuya,
- Frederic Gottrand,
- Nitika Gupta,
- Matjaž Homan,
- M.K. Jensen,
- Binita M. Kamath,
- Kyung Mo Kim,
- Kaija‐Leena Kolho,
- Anastasia Konidari,
- Bart Koot,
- Raffaele Iorio,
- Mercedes Martinez,
- Parvathi Mohan,
- Sirish Palle,
- Alexandra Papadopoulou,
- Amanda Ricciuto,
- Lawrence Saubermann,
- Pushpa Sathya,
- Eyal Shteyer,
- Vratislav Smolka,
- Atsushi Tanaka,
- Pamela L. Valentino,
- Raghu Varier,
- Veena Venkat,
- Bernadette Vitola,
- Miriam B. Vos,
- Marek Woynarowski,
- Jason Yap,
- Tamir Miloh
Affiliations
- Mark R. Deneau
- University of Utah Salt Lake City UT
- Cara Mack
- University of Colorado School of Medicine Aurora CO
- Reham Abdou
- Nassau University Medical Center East Meadow NY
- Mansi Amin
- Phoenix Children’s Hospital Phoenix AZ
- Achiya Amir
- Dana‐Dwek Children’s Hospital, Tel‐Aviv Medical Center, Tel‐Aviv University Tel Aviv Israel
- Marcus Auth
- Alder Hey Children’s Hospital Liverpool United Kingdom
- Fateh Bazerbachi
- Mayo Clinic Rochester MN
- Anne Marie Broderick
- University College Dublin Dublin Ireland
- Albert Chan
- University of Rochester Medical Center Rochester NY
- Matthew DiGuglielmo
- Nemours Alfred I duPont Hospital For Children Wilmington DE
- Wael El‐Matary
- University of Manitoba Winnipeg Canada
- Mounif El‐Youssef
- Mayo Clinic Rochester MN
- Federica Ferrari
- Sapienza University of Rome Rome Italy
- Katryn N. Furuya
- Mayo Clinic Rochester MN
- Frederic Gottrand
- Lille University Hospital of Lille Lille France
- Nitika Gupta
- Emory University School of Medicine Atlanta GA
- Matjaž Homan
- University of Ljubljana Ljubljana Slovenia
- M.K. Jensen
- University of Utah Salt Lake City UT
- Binita M. Kamath
- University of Toronto Toronto Canada
- Kyung Mo Kim
- University of Ulsan Seoul South Korea
- Kaija‐Leena Kolho
- University of Helsinki Helsinki Finland
- Anastasia Konidari
- University of Liverpool Liverpool United Kingdom
- Bart Koot
- Academic Medical Centre Amsterdam the Netherlands
- Raffaele Iorio
- University of Naples Federico II Naples Italy
- Mercedes Martinez
- Columbia University College of Physicians and Surgeons New York NY
- Parvathi Mohan
- Children’s National Medical Center Washington DC
- Sirish Palle
- Emory University School of Medicine Atlanta GA
- Alexandra Papadopoulou
- University of Athens Athens Greece
- Amanda Ricciuto
- University of Toronto Toronto Canada
- Lawrence Saubermann
- University of Rochester Medical Center Rochester NY
- Pushpa Sathya
- Memorial University St. John’s, Newfoundland and Labrador Canada
- Eyal Shteyer
- Shaare Zedek Medical Center Jerusalem Israel
- Vratislav Smolka
- Palacky University Olomouc Czech Republic
- Atsushi Tanaka
- Teikyo University School of Medicine Tokyo Japan
- Pamela L. Valentino
- Yale University School of Medicine New Haven CT
- Raghu Varier
- Northwest Pediatric Gastroenterology LLC Portland OR
- Veena Venkat
- University of Pittsburgh Medical Center Pittsburgh PA
- Bernadette Vitola
- Medical College of Wisconsin Milwaukee WI
- Miriam B. Vos
- Emory University School of Medicine Atlanta GA
- Marek Woynarowski
- Children’s Health Memorial Institute Warsaw Poland
- Jason Yap
- University of Alberta Edmonton Canada
- Tamir Miloh
- Phoenix Children’s Hospital Phoenix AZ
- DOI
- https://doi.org/10.1002/hep4.1251
- Journal volume & issue
-
Vol. 2,
no. 11
pp. 1369 – 1378
Abstract
Adverse clinical events in primary sclerosing cholangitis (PSC) happen too slowly to capture during clinical trials. Surrogate endpoints are needed, but no such validated endpoints exist for children with PSC. We evaluated the association between gamma glutamyltransferase (GGT) reduction and long‐term outcomes in pediatric PSC patients. We evaluated GGT normalization ( 75% versus 75% by 1 year after PSC diagnosis predicts favorable 5‐year outcomes in children. GGT has promise as a potential surrogate endpoint in future clinical trials for pediatric PSC.
