Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging

Jourdan H. Parent; Claire J. Ciampa; Theresa M. Harrison; Jenna N. Adams; Kailin Zhuang; Matthew J. Betts; Anne Maass; Joseph R. Winer; William J. Jagust; Anne S. Berry

NeuroImage (Nov 2022)

Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging

Jourdan H. Parent,
Claire J. Ciampa,
Theresa M. Harrison,
Jenna N. Adams,
Kailin Zhuang,
Matthew J. Betts,
Anne Maass,
Joseph R. Winer,
William J. Jagust,
Anne S. Berry

Affiliations

Jourdan H. Parent: Department of Psychology, Brandeis University, Waltham, MA, 02453, USA; Corresponding authors: 415 South Street MS062, Waltham MA 02453, USA.
Claire J. Ciampa: Department of Psychology, Brandeis University, Waltham, MA, 02453, USA
Theresa M. Harrison: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA
Jenna N. Adams: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA
Kailin Zhuang: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA
Matthew J. Betts: Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University, Magdeburg, 39106, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen, Magdeburg, 39120, Germany; Center for Behavioral Brain Sciences, University of Magdeburg, Magdeburg, Germany
Anne Maass: Deutsches Zentrum für Neurodegenerative Erkrankungen, Magdeburg, 39120, Germany
Joseph R. Winer: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA
William J. Jagust: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, 94720, USA; Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA
Anne S. Berry: Department of Psychology, Brandeis University, Waltham, MA, 02453, USA; Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA; Corresponding authors: 415 South Street MS062, Waltham MA 02453, USA.

Journal volume & issue: Vol. 263
p. 119658

Abstract

Read online

Higher neuroticism is a risk factor for Alzheimer's disease (AD), and is implicated in disordered stress responses. The locus coeruleus (LC)-catecholamine system is activated during perceived threat and is a centerpiece of developing models of the pathophysiology of AD, as it is the first brain region to develop abnormal tau. We examined relationships among the “Big 5” personality traits, LC catecholamine synthesis capacity measured with [18F]Fluoro-m-tyrosine PET, and tau burden measured with [18F]Flortaucipir PET in cognitively normal older adults (n = 47). β-amyloid (Aβ) status was determined using [11C]Pittsburgh compound B PET (n = 14 Aβ positive). Lower LC catecholamine synthesis capacity was associated with higher neuroticism, more depressive symptoms as measured by the Geriatric Depression Scale, and higher amygdala tau-PET binding. Exploratory analyses with other personality traits revealed that low trait conscientiousness was also related to both lower LC catecholamine synthesis capacity, and more depressive symptoms. A significant indirect path linked both high neuroticism and low conscientiousness to greater amygdala tau burden via their mutual association with low LC catecholamine synthesis capacity. Together, these findings reveal LC catecholamine synthesis capacity to be a promising marker of affective health and pathology burden in aging, and identifies candidate neurobiological mechanisms for the effect of personality on increased vulnerability to dementia.

Published in NeuroImage

ISSN: 1053-8119 (Print); 1095-9572 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neuroimage

About the journal

Abstract

Keywords