Nature Communications (Oct 2020)

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae

  • Kevin C. Ma,
  • Tatum D. Mortimer,
  • Marissa A. Duckett,
  • Allison L. Hicks,
  • Nicole E. Wheeler,
  • Leonor Sánchez-Busó,
  • Yonatan H. Grad

DOI
https://doi.org/10.1038/s41467-020-19250-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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The mechanisms underlying resistance of Neisseria gonorrhoeae to the antibiotic azithromycin are incompletely understood. Here, Ma et al. conduct a conditional genome-wide association study to identify new resistance mutations and experimentally confirm that a mutation in ribosomal protein L4 confers increased resistance.