AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

Jiangman Lou; Hongxia Chen; Jinhua Han; Hanqing He; Michael S. Y. Huen; Xin-hua Feng; Ting Liu; Jun Huang

doi:10.1038/s41467-017-01151-w

Nature Communications (Oct 2017)

AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

Jiangman Lou,
Hongxia Chen,
Jinhua Han,
Hanqing He,
Michael S. Y. Huen,
Xin-hua Feng,
Ting Liu,
Jun Huang

Affiliations

Jiangman Lou: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou
Hongxia Chen: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou
Jinhua Han: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou
Hanqing He: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou
Michael S. Y. Huen: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region
Xin-hua Feng: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou
Ting Liu: Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou
Jun Huang: Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou

DOI: https://doi.org/10.1038/s41467-017-01151-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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DNA double strand breaks can be repaired by homology-independent or homology-directed mechanisms. The choice between these pathways is a key event for genomic stability maintenance. Here the authors identify and characterize AUNIP, as a factor involved in tilting the balance towards homology repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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