Frontiers in Neuroscience (Jun 2022)
The Enhanced Interhemispheric Functional Connectivity in the Striatum Is Related to the Cognitive Impairment in Individuals With White Matter Hyperintensities
- Huahong Zhu,
- Huahong Zhu,
- Huahong Zhu,
- Huahong Zhu,
- Huahong Zhu,
- Huahong Zhu,
- Ruomeng Qin,
- Ruomeng Qin,
- Ruomeng Qin,
- Ruomeng Qin,
- Ruomeng Qin,
- Yue Cheng,
- Yue Cheng,
- Yue Cheng,
- Yue Cheng,
- Yue Cheng,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Pengfei Shao,
- Pengfei Shao,
- Pengfei Shao,
- Pengfei Shao,
- Pengfei Shao,
- Hengheng Xu,
- Hengheng Xu,
- Hengheng Xu,
- Hengheng Xu,
- Hengheng Xu,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Qing Ye,
- Qing Ye,
- Qing Ye,
- Qing Ye,
- Qing Ye
Affiliations
- Huahong Zhu
- Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China
- Huahong Zhu
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Huahong Zhu
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Huahong Zhu
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Huahong Zhu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Huahong Zhu
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- Ruomeng Qin
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Ruomeng Qin
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Ruomeng Qin
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Ruomeng Qin
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Ruomeng Qin
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- Yue Cheng
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Yue Cheng
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Yue Cheng
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Yue Cheng
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Yue Cheng
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- Lili Huang
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Lili Huang
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Lili Huang
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Lili Huang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Lili Huang
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- Pengfei Shao
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Pengfei Shao
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Pengfei Shao
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Pengfei Shao
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Pengfei Shao
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- Hengheng Xu
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Hengheng Xu
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Hengheng Xu
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Hengheng Xu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Hengheng Xu
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- Yun Xu
- Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China
- Yun Xu
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Yun Xu
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Yun Xu
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Yun Xu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Yun Xu
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- Qing Ye
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
- Qing Ye
- Institute for Brain Sciences, Nanjing University, Nanjing, China
- Qing Ye
- Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China
- Qing Ye
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Qing Ye
- Nanjing Neurology Clinic Medical Center, Nanjing, China
- DOI
- https://doi.org/10.3389/fnins.2022.899473
- Journal volume & issue
-
Vol. 16
Abstract
ObjectiveThe cognitive performance of individuals with white matter hyperintensities (WMH) tends to vary considerably. This study aimed to explore the relationship of the synchronous spontaneous activities in homotopic areas across hemispheres, named as voxel-mirrored homotopic connectivity (VMHC), with the cognitive performance of individuals with WMH.Materials and MethodsEighty-two WMH subjects without cognitive impairment (CI), 56 WMH subjects with CI, and 92 healthy subjects (HS) underwent neuropsychological tests and multimodal magnetic resonance imaging scans. VMHC maps were analyzed among the three groups. Correlative analyses were performed between VMHC values and cognitive function.ResultsNo significant difference in WMH volume, brain volume, or gray matter atrophy rate was shown between WMH subjects with and without CI. In contrast, those with CI displayed lower VMHC in the bilateral cuneus and calcarine and higher VMHC in the lentiform nucleus and caudate nucleus (LNCN) than those without CI. Furthermore, the VMHC in the LNCN was negatively associated with the global function and the memory function in WMH subjects.ConclusionThe enhanced VMHC in the LNCN was associated with the development of CI in individuals with WMH. This finding may contribute to the exploration of surrogate markers for the CI caused by WMH.
Keywords
- white matter hyperintensities
- voxel-mirrored homotopic connectivity
- cognitive impairment
- cognitive heterogeneity
- functional magnetic resonance imaging
