Frontiers in Genetics (Sep 2022)

Characterization of fatty acid metabolism-related lncRNAs in lung adenocarcinoma identifying potential novel prognostic targets

  • Yang Liu,
  • Xingshu Zhang,
  • Xuechao Cheng,
  • Qian Luo,
  • Mingyang Yu,
  • Kaijun Long,
  • Wendong Qu,
  • Yang Tang,
  • Ming Gong,
  • Lubiao Liang,
  • Xixian Ke,
  • Yongxiang Song

DOI
https://doi.org/10.3389/fgene.2022.990153
Journal volume & issue
Vol. 13

Abstract

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Lung adenocarcinoma (LUAD), a malignant respiratory tumor with an extremely poor prognosis, has troubled the medical community all over the world. According to recent studies, fatty acid metabolism (FAM) and long non-coding RNAs (lncRNAs) regulation have shown exciting results in tumor therapy. In this study, the original LUAD patient data was obtained from the TCGA database, and 12 FAM-related lncRNAs (AL390755.1, AC105020.6, TMPO-AS1, AC016737.2, AC127070.2, LINC01281, AL589986.2, GAS6-DT, AC078993.1, LINC02198, AC007032.1, and AL021026.1) that were highly related to the progression of LUAD were finally identified through bioinformatics analysis, and a risk score model for clinical reference was constructed. The window explores the immunology and molecular mechanism of LUAD, aiming to shed the hoping light on LUAD treatment.

Keywords