Taiwanese Journal of Obstetrics & Gynecology (Oct 2016)
Uterine sarcoma part III—Targeted therapy: The Taiwan Association of Gynecology (TAG) systematic review
- Ming-Shyen Yen,
- Jen-Ruei Chen,
- Peng-Hui Wang,
- Kuo-Chang Wen,
- Yi-Jen Chen,
- Heung-Tat Ng,
- Yen-Hou Chang,
- Yi Chang,
- Hsiang-Tai Chao,
- Kuan-Chong Chao,
- Chi-Mu Chuang,
- Chi-Hong Ho,
- Huann-Cheng Horng,
- Chen-Yu Huang,
- Ling-Yu Jiang,
- Chia-Hao Liu,
- Hsin-Yang Li,
- Pi-Lin Sun,
- Hua-Hsi Wu,
- Fong-Yuan Ju,
- Chih-Ping Tsai,
- Wen-Hsun Chang,
- Yen-Mei Hsu,
- Shu-Yun Huang,
- Na-Rong Lee,
- Chih-Yao Chen,
- Wen-Chun Chang,
- Chii-Hou Chen,
- Ruey-Jian Chen,
- Song-Nan Chow,
- Yih-Ron Lien,
- Bor-Ching Sheu,
- Pao-Ling Torng,
- Lin-Hung Wei,
- Men-Luh Yen,
- Wen-Ling Lee,
- Kuan-Chin Wang,
- Chih-Long Chang,
- Chih-Ping Chen,
- Tze-Chien Chen,
- Jian-Pei Huang,
- Ming-Chao Huang,
- Yeou-Lih Wang,
- Cheng-Chang Chang,
- Jah-Yao Liu,
- Her-Young Su,
- Yu-Chi Wang,
- Mu-Hsien Yu,
- Ching-Chuang Chu,
- Lee-Wen Huang,
- Kok-Min Seow,
- Tsung-Hsuan Lai,
- Fa-Kung Lee,
- Ching-Hui Chen,
- Wei-Min Liu,
- Jyh-Shin Chiou,
- Ben-Shian Huang,
- Yen-Feng Lu,
- Sheng-Mou Hsiao,
- Hsu-Dong Sun,
- Wen-Yih Wu,
- Sen-Wen Teng,
- Kuo-Hu Chen,
- Jeng-Hsiu Hung,
- Hung-Cheng Lai,
- Chiou-Chung Yuan,
- Ching-Hung Hsieh,
- Chin-Jung Wang,
- Chia-Hao Chan,
- Shing-Jyh Chang,
- Chuan-Chi Shih,
- Man-Jung Hung,
- Shih-Tien Hsu,
- Yu-Min Ke,
- Chien-Hsing Lu,
- Lou Sun,
- Wei-Chun Chang,
- Yao-Ching Hung,
- Wu-Chou Lin,
- Po-Hui Wang,
- Tze-Ho Chen,
- Meng-Hsing Wu,
- Yiu-Tai Li,
- Kuo-Feng Huang,
- Fei-Chi Chuang,
- Hung-Chun Fu,
- Fu-Tsai Kung,
- Kuan-Hui Huang,
- San-Nung Chen,
- An-Jen Chiang,
- Ju-Yueh Li,
- Wen-Shiung Liou,
- Li-Te Lin,
- Hsiao-Wen Tsai,
- Kuan-Hao Tsui
Affiliations
- Ming-Shyen Yen
- Jen-Ruei Chen
- Peng-Hui Wang
- Kuo-Chang Wen
- Yi-Jen Chen
- Heung-Tat Ng
- Yen-Hou Chang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Yi Chang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hsiang-Tai Chao
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Kuan-Chong Chao
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chi-Mu Chuang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chi-Hong Ho
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Huann-Cheng Horng
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chen-Yu Huang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Ling-Yu Jiang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chia-Hao Liu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hsin-Yang Li
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Pi-Lin Sun
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hua-Hsi Wu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Fong-Yuan Ju
- Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Chih-Ping Tsai
- Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan
- Wen-Hsun Chang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Yen-Mei Hsu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Shu-Yun Huang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Na-Rong Lee
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chih-Yao Chen
- Dianthus MFM Center Minquan, Dianthus MFM Group, and National Yang-Ming University, Taipei, Taiwan
- Wen-Chun Chang
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Chii-Hou Chen
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Ruey-Jian Chen
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Song-Nan Chow
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Yih-Ron Lien
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Bor-Ching Sheu
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Pao-Ling Torng
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Lin-Hung Wei
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Men-Luh Yen
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Wen-Ling Lee
- Department of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan
- Kuan-Chin Wang
- Department of Nursing, Oriental Institute of Technology, New Taipei City, Taiwan
- Chih-Long Chang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Chih-Ping Chen
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Tze-Chien Chen
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Jian-Pei Huang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Ming-Chao Huang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Yeou-Lih Wang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Cheng-Chang Chang
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Jah-Yao Liu
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Her-Young Su
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Yu-Chi Wang
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Mu-Hsien Yu
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Ching-Chuang Chu
- Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- Lee-Wen Huang
- Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- Kok-Min Seow
- Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- Tsung-Hsuan Lai
- Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan
- Fa-Kung Lee
- Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan
- Ching-Hui Chen
- Department of Obstetrics and Gynecology, Taipei Medical University Hospital and Taipei Medical University, Taipei, Taiwan
- Wei-Min Liu
- Department of Obstetrics and Gynecology, Taipei Medical University Hospital and Taipei Medical University, Taipei, Taiwan
- Jyh-Shin Chiou
- Department of Obstetrics and Gynecology, National Yang-Ming University Hospital, Ilan, Taiwan
- Ben-Shian Huang
- Department of Obstetrics and Gynecology, National Yang-Ming University Hospital, Ilan, Taiwan
- Yen-Feng Lu
- Department of Obstetrics and Gynecology, National Yang-Ming University Hospital, Ilan, Taiwan
- Sheng-Mou Hsiao
- Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Hsu-Dong Sun
- Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Wen-Yih Wu
- Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Sen-Wen Teng
- Department of Obstetrics and Gynecology, Cardinal Tien Hospital-Hsintien and Fu Jen Catholic University, New Taipei City, Taiwan
- Kuo-Hu Chen
- Department of Obstetrics and Gynecology, Taipei Buddhist Tzu Chi General Hospital, New Taipei City, Taiwan
- Jeng-Hsiu Hung
- Department of Obstetrics and Gynecology, Taipei Buddhist Tzu Chi General Hospital, New Taipei City, Taiwan
- Hung-Cheng Lai
- Department of Obstetrics and Gynecology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan
- Chiou-Chung Yuan
- Department of Obstetrics and Gynecology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan
- Ching-Hung Hsieh
- Department of Obstetrics and Gynecology, Clinic of Fu Jen Catholic University, New Taipei City, Taiwan
- Chin-Jung Wang
- Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, and Chang Gung University, Taoyuan, Taiwan
- Chia-Hao Chan
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Hsinchu, Taiwan
- Shing-Jyh Chang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Hsinchu, Taiwan
- Chuan-Chi Shih
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Hsinchu, Taiwan
- Man-Jung Hung
- Department of Obstetrics and Gynecology, Asia University Hospital, Taichung, Taiwan
- Shih-Tien Hsu
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Yu-Min Ke
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Chien-Hsing Lu
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Lou Sun
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Wei-Chun Chang
- Department of Obstetrics and Gynecology, China Medical University Hospital and China Medical University, Taichung, Taiwan
- Yao-Ching Hung
- Department of Obstetrics and Gynecology, China Medical University Hospital and China Medical University, Taichung, Taiwan
- Wu-Chou Lin
- Department of Obstetrics and Gynecology, China Medical University Hospital and China Medical University, Taichung, Taiwan
- Po-Hui Wang
- Department of Obstetrics and Gynecology, Chung-Shang General Hospital and Chung-Shang Medical University, Taichung, Taiwan
- Tze-Ho Chen
- Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
- Meng-Hsing Wu
- Department of Obstetrics and Gynecology, National Cheng Kung University Hospital and National Cheng Kung University, Tainan, Taiwan
- Yiu-Tai Li
- Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan
- Kuo-Feng Huang
- Department of Obstetrics and Gynecology, Chi-Mei Medical Center, Tainan, Taiwan
- Fei-Chi Chuang
- Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
- Hung-Chun Fu
- Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
- Fu-Tsai Kung
- Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
- Kuan-Hui Huang
- Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
- San-Nung Chen
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- An-Jen Chiang
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Ju-Yueh Li
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Wen-Shiung Liou
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Li-Te Lin
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Hsiao-Wen Tsai
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Kuan-Hao Tsui
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- DOI
- https://doi.org/10.1016/j.tjog.2016.07.001
- Journal volume & issue
-
Vol. 55,
no. 5
pp. 625 – 634
Abstract
Uterine sarcoma is a very aggressive and highly lethal disease. Even after a comprehensive staging surgery or en block cytoreduction surgery followed by multimodality therapy (often chemotherapy and/or radiation therapy), many patients relapse or present with distant metastases, and finally die of diseases. The worst outcome of uterine sarcomas is partly because of their rarity, unknown etiology, and highly divergent genetic aberration. Uterine sarcomas are often classified into four distinct subtypes, including uterine leiomyosarcoma, low-grade uterine endometrial stromal sarcoma, high-grade uterine endometrial stromal sarcoma, and undifferentiated uterine sarcoma. Currently, evidence from tumor biology found that these tumors showed alternation and/or mutation of genomes and the intracellular signal pathway. In addition, some preclinical studies showed promising results for targeting receptor tyrosine kinase signaling, phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway, various kinds of growth factor pathways, Wnt/beta-catenin signaling pathway, transforming growth factor β/bone morphogenetic protein signal pathway, aurora kinase A, MDM2 proto-oncogene, histone deacetylases, sex hormone receptors, certain types of oncoproteins, and/or loss of tumor suppressor genes. The current review is attempted to summarize the recurrent advance of targeted therapy for uterine sarcomas.
Keywords
