Nature Communications (Jul 2017)
Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
- Tuo Deng,
- Joey Liu,
- Yanru Deng,
- Laurie Minze,
- Xiang Xiao,
- Valerie Wright,
- Richeng Yu,
- Xian C. Li,
- Alecia Blaszczak,
- Stephen Bergin,
- David DiSilvestro,
- Ryan Judd,
- David Bradley,
- Michael Caligiuri,
- Christopher J. Lyon,
- Willa A. Hsueh
Affiliations
- Tuo Deng
- Center for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College
- Joey Liu
- Department of Internal Medicine, Division of Endocrinology, The Diabetes and Metabolism Research Center, Diabetes and Metabolism, The Ohio State University
- Yanru Deng
- Center for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College
- Laurie Minze
- Immunobiology and Transplantation Research, Houston Methodist Research Institute, Texas Medical Center
- Xiang Xiao
- Immunobiology and Transplantation Research, Houston Methodist Research Institute, Texas Medical Center
- Valerie Wright
- Department of Internal Medicine, Division of Endocrinology, The Diabetes and Metabolism Research Center, Diabetes and Metabolism, The Ohio State University
- Richeng Yu
- Center for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College
- Xian C. Li
- Immunobiology and Transplantation Research, Houston Methodist Research Institute, Texas Medical Center
- Alecia Blaszczak
- Department of Internal Medicine, Division of Endocrinology, The Diabetes and Metabolism Research Center, Diabetes and Metabolism, The Ohio State University
- Stephen Bergin
- The Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University
- David DiSilvestro
- Department of Internal Medicine, Division of Endocrinology, The Diabetes and Metabolism Research Center, Diabetes and Metabolism, The Ohio State University
- Ryan Judd
- Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University
- David Bradley
- Department of Internal Medicine, Division of Endocrinology, The Diabetes and Metabolism Research Center, Diabetes and Metabolism, The Ohio State University
- Michael Caligiuri
- Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University
- Christopher J. Lyon
- Center for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College
- Willa A. Hsueh
- Department of Internal Medicine, Division of Endocrinology, The Diabetes and Metabolism Research Center, Diabetes and Metabolism, The Ohio State University
- DOI
- https://doi.org/10.1038/ncomms15725
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Obesity is associated with inflammation in adipose tissue, characterized by a shift in local T cell subsets. Here the authors show that loss of MHCII expression on adipocytes increases levels of immunosuppressive regulatory T cells in adipose tissue, which enhances insulin sensitivity.
