Brain and Behavior (Oct 2021)
Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses
- Lonneke A. vanTuijl,
- Adri C. Voogd,
- Alexander deGraeff,
- Adriaan W. Hoogendoorn,
- Adelita V. Ranchor,
- Kuan‐Yu Pan,
- Maartje Basten,
- Femke Lamers,
- Mirjam I. Geerlings,
- Jessica G. Abell,
- Philip Awadalla,
- Marije F. Bakker,
- Aartjan T. F. Beekman,
- Ottar Bjerkeset,
- Andy Boyd,
- Yunsong Cui,
- Henrike Galenkamp,
- Bert Garssen,
- Sean Hellingman,
- Martijn Huisman,
- Anke Huss,
- Melanie R. Keats,
- Almar A. L. Kok,
- Annemarie I. Luik,
- Nolwenn Noisel,
- N. Charlotte Onland‐Moret,
- Yves Payette,
- Brenda W. J. H. Penninx,
- Lützen Portengen,
- Ina Rissanen,
- Annelieke M. Roest,
- Judith G. M. Rosmalen,
- Rikje Ruiter,
- Robert A. Schoevers,
- David M. Soave,
- Mandy Spaan,
- Andrew Steptoe,
- Karien Stronks,
- Erik R. Sund,
- Ellen Sweeney,
- Alison Teyhan,
- Ilonca Vaartjes,
- Kimberly D. van derWillik,
- Flora E. vanLeeuwen,
- Rutger vanPetersen,
- W. M. Monique Verschuren,
- Frank Visseren,
- Roel Vermeulen,
- Joost Dekker
Affiliations
- Lonneke A. vanTuijl
- Department of Internal Medicine Maasstad Hospital Rotterdam The Netherlands
- Adri C. Voogd
- Department of Internal Medicine Division of Medical Oncology GROW Maastricht University Medical Centre Maastricht The Netherlands
- Alexander deGraeff
- Department of Medical Oncology Cancer Center University Medical Center University of Utrecht Utrecht The Netherlands
- Adriaan W. Hoogendoorn
- Amsterdam UMC Department of Psychiatry Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam The Netherlands
- Adelita V. Ranchor
- Department of Internal Medicine Maasstad Hospital Rotterdam The Netherlands
- Kuan‐Yu Pan
- Amsterdam UMC Department of Psychiatry Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam The Netherlands
- Maartje Basten
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- Femke Lamers
- Amsterdam UMC Department of Psychiatry Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam The Netherlands
- Mirjam I. Geerlings
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- Jessica G. Abell
- Department of Behavioural Science and Health University College London London UK
- Philip Awadalla
- Ontario Institute for Cancer Research Toronto Ontario Canada
- Marije F. Bakker
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- Aartjan T. F. Beekman
- Amsterdam UMC Department of Psychiatry Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam The Netherlands
- Ottar Bjerkeset
- Faculty of Nursing and Health Sciences Nord University Bodø Norway
- Andy Boyd
- Bristol Medical School, Population Health Sciences University of Bristol Bristol UK
- Yunsong Cui
- Atlantic Partnership for Tomorrow's Health Faculty of Health Dalhousie University Halifax Nova Scotia Canada
- Henrike Galenkamp
- Department of Public and Occupational Health Amsterdam UMC and Amsterdam Public Health Research Institute University of Amsterdam Amsterdam Netherlands
- Bert Garssen
- Department of Internal Medicine Maasstad Hospital Rotterdam The Netherlands
- Sean Hellingman
- Department of Mathematics Wilfrid Laurier University Waterloo Canada
- Martijn Huisman
- Amsterdam UMC Department of Epidemiology & Data Science Amsterdam Public Health institute Vrije Universiteit Amsterdam Amsterdam The Netherlands
- Anke Huss
- Institute for Risk Assessment Sciences Utrecht University Utrecht The Netherlands
- Melanie R. Keats
- School of Health and Human Performance Faculty of Health Dalhousie University Halifax Canada
- Almar A. L. Kok
- Amsterdam UMC Department of Psychiatry Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam The Netherlands
- Annemarie I. Luik
- Department of Epidemiology Erasmus MC–University Medical Center Rotterdam The Netherlands
- Nolwenn Noisel
- CARTaGENE, CHU Sainte‐Justine, 3175 Chemin de la Côte‐Sainte‐Catherine Montréal Québec Canada
- N. Charlotte Onland‐Moret
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- Yves Payette
- CARTaGENE, CHU Sainte‐Justine, 3175 Chemin de la Côte‐Sainte‐Catherine Montréal Québec Canada
- Brenda W. J. H. Penninx
- Amsterdam UMC Department of Psychiatry Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam The Netherlands
- Lützen Portengen
- Institute for Risk Assessment Sciences Utrecht University Utrecht The Netherlands
- Ina Rissanen
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- Annelieke M. Roest
- Department of Developmental Psychology University of Groningen Groningen The Netherlands
- Judith G. M. Rosmalen
- Departments of Psychiatry and Internal Medicine University Medical Center Groningen University of Groningen Groningen The Netherlands
- Rikje Ruiter
- Department of Epidemiology Erasmus MC–University Medical Center Rotterdam The Netherlands
- Robert A. Schoevers
- Department of Psychiatry University Medical Center Groningen University of Groningen Groningen the Netherlands
- David M. Soave
- Department of Mathematics Wilfrid Laurier University Waterloo Canada
- Mandy Spaan
- Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute Amsterdam The Netherlands
- Andrew Steptoe
- Department of Behavioural Science and Health University College London London UK
- Karien Stronks
- Department of Public and Occupational Health Amsterdam UMC and Amsterdam Public Health Research Institute University of Amsterdam Amsterdam Netherlands
- Erik R. Sund
- Faculty of Nursing and Health Sciences Nord University Bodø Norway
- Ellen Sweeney
- Atlantic Partnership for Tomorrow's Health Faculty of Health Dalhousie University Halifax Nova Scotia Canada
- Alison Teyhan
- Bristol Medical School, Population Health Sciences University of Bristol Bristol UK
- Ilonca Vaartjes
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- Kimberly D. van derWillik
- Department of Epidemiology Erasmus MC–University Medical Center Rotterdam The Netherlands
- Flora E. vanLeeuwen
- Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute Amsterdam The Netherlands
- Rutger vanPetersen
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- W. M. Monique Verschuren
- Julius Center for Health Sciences and Primary Care University Medical Center Utrecht and Utrecht University Utrecht the Netherlands
- Frank Visseren
- Department of Vascular Medicine University Medical Center Utrecht Utrecht The Netherlands
- Roel Vermeulen
- Institute for Risk Assessment Sciences Utrecht University Utrecht The Netherlands
- Joost Dekker
- Amsterdam Public Health Research Institute Amsterdam Noord‐Holland The Netherlands
- DOI
- https://doi.org/10.1002/brb3.2340
- Journal volume & issue
-
Vol. 11,
no. 10
pp. n/a – n/a
Abstract
Abstract Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking‐related, and alcohol‐related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods The psychosocial factors and cancer incidence (PSY‐CA) consortium was established involving experts in the field of (psycho‐)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two‐stage individual participant data (IPD) meta‐analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta‐analyses will be performed on the risk estimates (stage 2). Conclusion PSY‐CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta‐analyses.
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