Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery

Michal A. Elovitz; Pawel Gajer; Valerie Riis; Amy G. Brown; Michael S. Humphrys; Johanna B. Holm; Jacques Ravel

doi:10.1038/s41467-019-09285-9

Nature Communications (Mar 2019)

Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery

Michal A. Elovitz,
Pawel Gajer,
Valerie Riis,
Amy G. Brown,
Michael S. Humphrys,
Johanna B. Holm,
Jacques Ravel

Affiliations

Michal A. Elovitz: Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania
Pawel Gajer: Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine
Valerie Riis: Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania
Amy G. Brown: Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania
Michael S. Humphrys: Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine
Johanna B. Holm: Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine
Jacques Ravel: Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine

DOI: https://doi.org/10.1038/s41467-019-09285-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Here, Elovitz et al. investigate associations between cervicovaginal microbiota (CVM) and spontaneous preterm birth (sPTB) in a large cohort of African American and non-African American women, and find that CVM and local immune response early in pregnancy are associated with sPTB in an ethnicity-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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