Nature Communications (Apr 2022)
Synthetic cells with self-activating optogenetic proteins communicate with natural cells
- Omer Adir,
- Mia R. Albalak,
- Ravit Abel,
- Lucien E. Weiss,
- Gal Chen,
- Amit Gruber,
- Oskar Staufer,
- Yaniv Kurman,
- Ido Kaminer,
- Jeny Shklover,
- Janna Shainsky-Roitman,
- Ilia Platzman,
- Lior Gepstein,
- Yoav Shechtman,
- Benjamin A. Horwitz,
- Avi Schroeder
Affiliations
- Omer Adir
- The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion
- Mia R. Albalak
- The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion
- Ravit Abel
- The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion
- Lucien E. Weiss
- Department of Biomedical Engineering, Technion
- Gal Chen
- The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion
- Amit Gruber
- Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion
- Oskar Staufer
- Department for Cellular Biophysics, Max Planck Institute for Medical Research
- Yaniv Kurman
- The Andrew and Erna Viterbi Faculty of Electrical and Computer Engineering, Technion
- Ido Kaminer
- The Andrew and Erna Viterbi Faculty of Electrical and Computer Engineering, Technion
- Jeny Shklover
- The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion
- Janna Shainsky-Roitman
- The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion
- Ilia Platzman
- Department for Cellular Biophysics, Max Planck Institute for Medical Research
- Lior Gepstein
- Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion
- Yoav Shechtman
- Department of Biomedical Engineering, Technion
- Benjamin A. Horwitz
- Faculty of Biology, Technion - Israel Institute of Technology
- Avi Schroeder
- The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion
- DOI
- https://doi.org/10.1038/s41467-022-29871-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.
