Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy

Abstract

Abstract Background In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of autophagy-related genes in the lung tissues following melatonin administration. Results Data showed histopathological remodeling in lung tissues of the D group coincided with an elevated level of IL-6, Becline-1, LC3, and P62 compared to the control group (p 0.05). Conclusion Our results showed that melatonin injection can be effective in the amelioration of lung injury in diabetic mice presumably by modulating autophagy-related genes.

Keywords

• Autophagy
• Diabetes
• Lung injury
• Melatonin