Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Abstract

Abstract Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM cells in the CD8+ population dramatically decreased together with increases in TEM and TEF cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in TSCM and TCM together with the increase in differentiated TEM and TEF subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients.

Keywords

• Stem cell memory T cells
• Central memory T cells
• Effector memory T cells
• CD8+ T cells
• Acute myeloid leukemia
• Bone marrow