Journal of the Formosan Medical Association (Jan 2022)
Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group
- Wan-Ling Ho,
- Giun-Yi Hung,
- Hsiu-Ju Yen,
- Yung-Li Yang,
- Hsiu-Hao Chang,
- Meng-Yao Lu,
- Kai-Hsin Lin,
- Jiann-Shiuh Chen,
- Chao-Neng Cheng,
- Iou-Jih Hung,
- Chao-Ping Yang,
- Shih-Hsiang Chen,
- Hsi-Che Liu,
- Ting-Chi Yeh,
- Jen-Yin Hou,
- Chih-Cheng Hsiao,
- Jiunn-Ming Sheen,
- Tai-Tsung Chang,
- Tai-Tong Wong,
- James S. Miser,
- Yen-Lin Liu,
- Rong-Long Chen,
- Bow-Wen Chen,
- Ching-Tien Peng,
- Te-Kau Chang,
- Kang-Hsi Wu,
- Yu-Hsiang Chang,
- Jinn-Li Wang,
- Shih-Chung Wang,
- Ming-Tsan Lin,
- Fu-Chang Hu,
- Shiann-Tarng Jou,
- Dong-Tsamn Lin
Affiliations
- Wan-Ling Ho
- School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
- Giun-Yi Hung
- Department of Pediatrics, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Hsiu-Ju Yen
- Department of Pediatrics, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Yung-Li Yang
- Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
- Hsiu-Hao Chang
- Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
- Meng-Yao Lu
- Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
- Kai-Hsin Lin
- Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
- Jiann-Shiuh Chen
- Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan
- Chao-Neng Cheng
- Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan
- Iou-Jih Hung
- Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, Taiwan
- Chao-Ping Yang
- Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, Taiwan
- Shih-Hsiang Chen
- Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, Taiwan
- Hsi-Che Liu
- Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, Taiwan
- Ting-Chi Yeh
- Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, Taiwan
- Jen-Yin Hou
- Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, Taiwan
- Chih-Cheng Hsiao
- Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
- Jiunn-Ming Sheen
- Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Pediatrics, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi, Taiwan
- Tai-Tsung Chang
- Ditmanson Foundation Chiayi Christian Hospital, Chiayi, Taiwan; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
- Tai-Tong Wong
- Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan
- James S. Miser
- Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan
- Yen-Lin Liu
- Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
- Rong-Long Chen
- Division of Pediatric Hematology and Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
- Bow-Wen Chen
- Division of Pediatric Hematology and Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
- Ching-Tien Peng
- Division of Pediatric Hematology & Oncology, Children's Hospital of China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Wufeng, Taichung, Taiwan
- Te-Kau Chang
- Division of Pediatric Hematology & Oncology, Children's Hospital of China Medical University, Taichung, Taiwan; Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan
- Kang-Hsi Wu
- Division of Pediatric Hematology & Oncology, Children's Hospital of China Medical University, Taichung, Taiwan; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
- Yu-Hsiang Chang
- Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Jinn-Li Wang
- Department of Pediatrics, Taipei Medical University–Wanfang Hospital, Taipei, Taiwan
- Shih-Chung Wang
- Division of Pediatric Hematology/Oncology, Changhua Christian Children's Hospital, Taiwan
- Ming-Tsan Lin
- Division of Pediatric Hematology/Oncology, Changhua Christian Children's Hospital, Taiwan
- Fu-Chang Hu
- Graduate Institute of Clinical Medicine and School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan; International-Harvard Statistical Consulting Company, Taipei, Taiwan
- Shiann-Tarng Jou
- Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, No.8, Chung Shan S. Rd., Zhongzheng Dist., Taipei 100226, Taiwan. Fax: +886 2 23147450.
- Dong-Tsamn Lin
- Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, No.8, Chung Shan S. Rd., Zhongzheng Dist., Taipei 100226, Taiwan. Fax: +886 2 23224263.
- Journal volume & issue
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Vol. 121,
no. 1
pp. 350 – 359
Abstract
Background: Patients with childhood cancer are at increased risk for the development of second cancers. Methods: A national multicenter survey of second cancers conducted by the Taiwan Pediatric Oncology Group retrieved retrospective data from the database at the Children Cancer Foundation in Taiwan beginning in 1995. The characteristics of second cancers and associations of patient demographic and clinical characteristics with time to death due to a second cancer were analyzed. Results: We examined the records of 8782 patients with a primary cancer diagnosed between January 1, 1995 and December 31, 2013, and a total of 99 patients with a second cancer were identified. The most common type of second cancer was acute myeloid leukemia (n = 35), followed by acute lymphoblastic leukemia (n = 15), central nervous system (CNS) tumors (n = 15), and sarcomas (n = 10). Secondary hematological malignancies occurred earlier than other secondary cancers. The frequencies of second CNS tumors and second bone cancers and sarcomas were notably increased when prior radiation doses increased from zero, low dose to high dose. The overall 5-year survival of patients with a second cancer was poor (33.7%). Multivariate survival analysis revealed that the year of primary diagnosis ≤2002, secondary hematological malignancies, and age at second cancer diagnosis ≤9.3 years or >26.8 years increased the risk of death following second cancer. Conclusion: Children who develop a second cancer have an unfavorable outcome. Early detection and improved treatment for second cancers are needed.
