Nature Communications (Dec 2022)
Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
- Filipa Mota,
- Camilo A. Ruiz-Bedoya,
- Elizabeth W. Tucker,
- Daniel P. Holt,
- Patricia De Jesus,
- Martin A. Lodge,
- Clara Erice,
- Xueyi Chen,
- Melissa Bahr,
- Kelly Flavahan,
- John Kim,
- Mary Katherine Brosnan,
- Alvaro A. Ordonez,
- Charles A. Peloquin,
- Robert F. Dannals,
- Sanjay K. Jain
Affiliations
- Filipa Mota
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Camilo A. Ruiz-Bedoya
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Elizabeth W. Tucker
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Daniel P. Holt
- Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine
- Patricia De Jesus
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Martin A. Lodge
- Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine
- Clara Erice
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Xueyi Chen
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Melissa Bahr
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Kelly Flavahan
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- John Kim
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Mary Katherine Brosnan
- Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine
- Alvaro A. Ordonez
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- Charles A. Peloquin
- Infectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of Pharmacy
- Robert F. Dannals
- Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine
- Sanjay K. Jain
- Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-35730-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the central nervous system, using positron emission tomography in animal models, and human studies.
