SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes

Vladislav N. Nikolov; Dhara Malavia; Takashi Kubota

doi:10.1038/s41467-022-29591-z

Nature Communications (Apr 2022)

SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes

Vladislav N. Nikolov,
Dhara Malavia,
Takashi Kubota

Affiliations

Vladislav N. Nikolov: Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill
Dhara Malavia: Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill
Takashi Kubota: Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill

DOI: https://doi.org/10.1038/s41467-022-29591-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The Pleiotropic Drug Resistance (PDR) network is central to drug response in fungi, and its overactivation is associated with drug resistance. Here the authors show that the chromatin remodeller SWI/SNF and the histone chaperone Rtt106 are important for PDR gene expression in fungi and therefore mediate resistance to antifungal drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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