Nature Communications (Jan 2021)
QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function
- Xinyun Chen,
- Ying Liu,
- Chen Xu,
- Lina Ba,
- Zhuo Liu,
- Xiuya Li,
- Jie Huang,
- Ed Simpson,
- Hongyu Gao,
- Dayan Cao,
- Wei Sheng,
- Hanping Qi,
- Hongrui Ji,
- Maria Sanderson,
- Chen-Leng Cai,
- Xiaohui Li,
- Lei Yang,
- Jie Na,
- Kenichi Yamamura,
- Yunlong Liu,
- Guoying Huang,
- Weinian Shou,
- Ning Sun
Affiliations
- Xinyun Chen
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University
- Ying Liu
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Chen Xu
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University
- Lina Ba
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Zhuo Liu
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Xiuya Li
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University
- Jie Huang
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University
- Ed Simpson
- Department of Bioinformatics, Indiana University School of Medicine
- Hongyu Gao
- Department of Bioinformatics, Indiana University School of Medicine
- Dayan Cao
- Institute of Materia Medica and Center of Translational Medicine, College of Pharmacy, Army Medical University
- Wei Sheng
- Shanghai Key Laboratory of Birth Defects, Children’s Hospital of Fudan University
- Hanping Qi
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Hongrui Ji
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Maria Sanderson
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Chen-Leng Cai
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Xiaohui Li
- Institute of Materia Medica and Center of Translational Medicine, College of Pharmacy, Army Medical University
- Lei Yang
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Jie Na
- Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
- Kenichi Yamamura
- Institute of Resource Development and Analysis, Kumanoto University
- Yunlong Liu
- Department of Bioinformatics, Indiana University School of Medicine
- Guoying Huang
- Shanghai Key Laboratory of Birth Defects, Children’s Hospital of Fudan University
- Weinian Shou
- Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine
- Ning Sun
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University
- DOI
- https://doi.org/10.1038/s41467-020-20327-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
RNA binding protein Quaking (QKI) is known for its broad function in pre-mRNA splicing and modification and its association with several neurodevelopmental disorders. Here the authors reveal that QKI-mediated regulation of RNA splicing is indispensable to cardiac development and contractile physiology.
