Side-chain Modifications of Highly Functionalized 3(2H)-Furanones

Abstract

A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide.

Keywords

• 3(2H)-furanone
• isoxazole
• natural products
• side-chain modifications