AIDS Research and Therapy (Dec 2010)

CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?

  • Silverberg Michael J,
  • Benson Constance A,
  • Collier Ann C,
  • Kirk Gregory D,
  • Jacobson Lisa P,
  • Martin Jeffrey N,
  • Deeks Steven G,
  • Sterling Timothy R,
  • Rodriguez Benigno,
  • Gill M John,
  • Rourke Sean B,
  • Napravnik Sonia,
  • Eron Joseph J,
  • Kitahata Mari M,
  • Saag Michael S,
  • Horberg Michael A,
  • Bosch Ronald J,
  • Hogg Robert S,
  • Brooks John T,
  • Klein Marina B,
  • Gange Stephen J,
  • Gebo Kelly A,
  • Althoff Keri N,
  • Goedert James J,
  • McKaig Rosemary G,
  • Thorne Jennifer,
  • Rachlis Anita,
  • Moore Richard D,
  • Justice Amy C

DOI
https://doi.org/10.1186/1742-6405-7-45
Journal volume & issue
Vol. 7, no. 1
p. 45

Abstract

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Abstract We assessed CD4 count at initial presentation for HIV care among ≥50-year-olds from 1997-2007 in 13 US and Canadian clinical cohorts and compared to 3) and 95% confidence intervals ([,]) were determined using linear regression stratified by age category and adjusted for gender, race/ethnicity, HIV transmission risk and cohort. From 1997-2007, the proportion of individuals presenting for HIV care who were ≥50-years-old increased from 17% to 27% (p-value 3; ≥50-year-olds: 7 [5 , 9] cells/mm3), after adjusting for sex, race/ethnicity, HIV transmission risk group and cohort; however, increases in the two groups were similar after 2000. A greater proportion of older individuals had an AIDS-defining diagnosis at, or within three months prior to, first presentation for HIV care compared to younger individuals (13% vs. 10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed.