Frontiers in Immunology (Jun 2022)
Can the cGAS-STING Pathway Play a Role in the Dry Eye?
- Weijie Ouyang,
- Weijie Ouyang,
- Weijie Ouyang,
- Weijie Ouyang,
- Weijie Ouyang,
- Shoubi Wang,
- Shoubi Wang,
- Shoubi Wang,
- Shoubi Wang,
- Shoubi Wang,
- Shoubi Wang,
- Shoubi Wang,
- Shoubi Wang,
- Jiaoyue Hu,
- Jiaoyue Hu,
- Jiaoyue Hu,
- Jiaoyue Hu,
- Jiaoyue Hu,
- Jiaoyue Hu,
- Zuguo Liu,
- Zuguo Liu,
- Zuguo Liu,
- Zuguo Liu,
- Zuguo Liu,
- Zuguo Liu,
- Zuguo Liu
Affiliations
- Weijie Ouyang
- Eye Institute of Xiamen University, Xiamen University, Xiamen, China
- Weijie Ouyang
- Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, China
- Weijie Ouyang
- Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, China
- Weijie Ouyang
- School of Medicine, Xiamen University, Xiamen, China
- Weijie Ouyang
- Department of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen University, Xiamen, China
- Shoubi Wang
- Eye Institute of Xiamen University, Xiamen University, Xiamen, China
- Shoubi Wang
- Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, China
- Shoubi Wang
- Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, China
- Shoubi Wang
- School of Medicine, Xiamen University, Xiamen, China
- Shoubi Wang
- Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Xiamen University, Xiamen, China
- Shoubi Wang
- Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen University, Xiamen, China
- Shoubi Wang
- Xiamen Diabetes Prevention and Treatment Center, Xiamen University, Xiamen, China
- Shoubi Wang
- Fujian Key Laboratory of Diabetes Translational Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
- Jiaoyue Hu
- Eye Institute of Xiamen University, Xiamen University, Xiamen, China
- Jiaoyue Hu
- Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, China
- Jiaoyue Hu
- Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, China
- Jiaoyue Hu
- School of Medicine, Xiamen University, Xiamen, China
- Jiaoyue Hu
- Department of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen University, Xiamen, China
- Jiaoyue Hu
- 0Xiamen University Affiliated Xiamen Eye Center, Xiamen, China
- Zuguo Liu
- Eye Institute of Xiamen University, Xiamen University, Xiamen, China
- Zuguo Liu
- Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, China
- Zuguo Liu
- Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, China
- Zuguo Liu
- School of Medicine, Xiamen University, Xiamen, China
- Zuguo Liu
- Department of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen University, Xiamen, China
- Zuguo Liu
- 0Xiamen University Affiliated Xiamen Eye Center, Xiamen, China
- Zuguo Liu
- 1Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, China
- DOI
- https://doi.org/10.3389/fimmu.2022.929230
- Journal volume & issue
-
Vol. 13
Abstract
Dry eye is one of the most common ocular surface diseases in the world and seriously affects the quality of life of patients. As an immune-related disease, the mechanism of dry eye has still not been fully elucidated. The cGAS-STING pathway is a recently discovered pathway that plays an important role in autoimmune and inflammatory diseases by recognizing dsDNA. As an important signal to initiate inflammation, the release of dsDNA is associated with dry eye. Herein, we focused on the pathophysiology of the immune-inflammatory response in the pathogenesis of dry eye, attempted to gain insight into the involvement of dsDNA in the dry eye immune response, and investigated the mechanism of the cGAS-STING pathway involved in the immune-inflammatory response. We further proposed that the cGAS-STING pathway may participate in dry eye as a new mechanism linking dry eye and the immune-inflammatory response, thus providing a new direction for the mechanistic exploration of dry eye.
Keywords
