Nature Communications (Jun 2021)
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
- Thomas Dahlet,
- Matthias Truss,
- Ute Frede,
- Hala Al Adhami,
- Anaïs F. Bardet,
- Michael Dumas,
- Judith Vallet,
- Johana Chicher,
- Philippe Hammann,
- Sarah Kottnik,
- Peter Hansen,
- Uschi Luz,
- Gonzalo Alvarez,
- Ghislain Auclair,
- Jochen Hecht,
- Peter N. Robinson,
- Christian Hagemeier,
- Michael Weber
Affiliations
- Thomas Dahlet
- University of Strasbourg
- Matthias Truss
- Pediatric Oncology, Labor für Pädiatrische Molekularbiologie, Charité - Universitätsmedizin Berlin
- Ute Frede
- Pediatric Oncology, Labor für Pädiatrische Molekularbiologie, Charité - Universitätsmedizin Berlin
- Hala Al Adhami
- University of Strasbourg
- Anaïs F. Bardet
- University of Strasbourg
- Michael Dumas
- University of Strasbourg
- Judith Vallet
- University of Strasbourg
- Johana Chicher
- Plateforme protéomique Strasbourg Esplanade, CNRS, University of Strasbourg
- Philippe Hammann
- Plateforme protéomique Strasbourg Esplanade, CNRS, University of Strasbourg
- Sarah Kottnik
- Pediatric Oncology, Labor für Pädiatrische Molekularbiologie, Charité - Universitätsmedizin Berlin
- Peter Hansen
- Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin
- Uschi Luz
- Pediatric Oncology, Labor für Pädiatrische Molekularbiologie, Charité - Universitätsmedizin Berlin
- Gonzalo Alvarez
- Pediatric Oncology, Labor für Pädiatrische Molekularbiologie, Charité - Universitätsmedizin Berlin
- Ghislain Auclair
- University of Strasbourg
- Jochen Hecht
- Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin
- Peter N. Robinson
- Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin
- Christian Hagemeier
- Pediatric Oncology, Labor für Pädiatrische Molekularbiologie, Charité - Universitätsmedizin Berlin
- Michael Weber
- University of Strasbourg
- DOI
- https://doi.org/10.1038/s41467-021-23596-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.
