Nature Communications (May 2020)
Multiplex precise base editing in cynomolgus monkeys
- Wenhui Zhang,
- Tomomi Aida,
- Ricardo C. H. del Rosario,
- Jonathan J. Wilde,
- Chenhui Ding,
- Xiaohui Zhang,
- Zulqurain Baloch,
- Yan Huang,
- Yu Tang,
- Duanduan Li,
- Hongyu Lu,
- Yang Zhou,
- Minqing Jiang,
- Dongdong Xu,
- Zhihao Fang,
- Zhanhong Zheng,
- Qunshan Huang,
- Guoping Feng,
- Shihua Yang
Affiliations
- Wenhui Zhang
- College of Veterinary Medicine, South China Agricultural University
- Tomomi Aida
- McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology
- Ricardo C. H. del Rosario
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Jonathan J. Wilde
- McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology
- Chenhui Ding
- Key Laboratory of Reproductive Medicine of Guangdong Province, Reproductive Medicine Center, the First Affiliated Hospital of Sun Yat-sen University
- Xiaohui Zhang
- Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
- Zulqurain Baloch
- College of Veterinary Medicine, South China Agricultural University
- Yan Huang
- College of Veterinary Medicine, South China Agricultural University
- Yu Tang
- College of Veterinary Medicine, South China Agricultural University
- Duanduan Li
- College of Veterinary Medicine, South China Agricultural University
- Hongyu Lu
- College of Veterinary Medicine, South China Agricultural University
- Yang Zhou
- McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology
- Minqing Jiang
- McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology
- Dongdong Xu
- College of Veterinary Medicine, South China Agricultural University
- Zhihao Fang
- College of Veterinary Medicine, South China Agricultural University
- Zhanhong Zheng
- College of Veterinary Medicine, South China Agricultural University
- Qunshan Huang
- College of Veterinary Medicine, South China Agricultural University
- Guoping Feng
- McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology
- Shihua Yang
- College of Veterinary Medicine, South China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-020-16173-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.
