Frontiers in Oncology (Jun 2021)

The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens

  • Ying Li,
  • Jun Ma,
  • Ziteng Song,
  • Yinan Zhao,
  • Han Zhang,
  • Yeling Li,
  • Jing Xu,
  • Yuanqiang Guo

DOI
https://doi.org/10.3389/fonc.2021.688195
Journal volume & issue
Vol. 11

Abstract

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Casearlucin A, a diterpenoid obtained from Casearia graveolens, has been reported to possess strong cytotoxic activity. However, the in vivo anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage and induced cell apoptosis in cell level. Additionally, casearlucin A inhibited HepG2 cell migration via regulating a few of metastasis-related proteins. Furthermore, it inhibited tumor angiogenesis in zebrafish in vivo. More importantly, casearlucin A significantly inhibited cell proliferation and migration in an in vivo zebrafish xenograft model. Collectively, these results are valuable for the further development and application of casearlucin A as an anticancer agent.

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