Nature Communications (Jul 2021)

GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms

  • Lucas D. Ward,
  • Ho-Chou Tu,
  • Chelsea B. Quenneville,
  • Shira Tsour,
  • Alexander O. Flynn-Carroll,
  • Margaret M. Parker,
  • Aimee M. Deaton,
  • Patrick A. J. Haslett,
  • Luca A. Lotta,
  • Niek Verweij,
  • Manuel A. R. Ferreira,
  • Regeneron Genetics Center,
  • Geisinger-Regeneron DiscovEHR Collaboration,
  • Aris Baras,
  • Gregory Hinkle,
  • Paul Nioi

DOI
https://doi.org/10.1038/s41467-021-24563-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Circulating liver enzymes, like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are highly heritable and predictive of disease. Here, the authors perform a genome-wide association study on ALT and AST, revealing a rare variant in SLC30A10 associated with elevated ALT and AST.