First Stereoselective Total Synthesis of Ciryneol C

Abstract

Abstract The acetylene derivative Ciryneol C was isolated from the roots of C. japonicum. The asymmetric total synthesis of Ciryneol C was achieved in seven steps, with Horner–Wittig olefination, regioselective epoxide opening, and Cadiot–Chodkiewicz coupling reactions being the key steps.

Keywords

• acetylene
• cadiot–chodkiewicz coupling
• natural products
• sharpless asymmetric epoxidation
• total synthesis