Nature Communications (Jul 2021)

Structural basis for recognition and regulation of arenavirus polymerase L by Z protein

  • Huiling Kang,
  • Jingyuan Cong,
  • Chenlong Wang,
  • Wenxin Ji,
  • Yuhui Xin,
  • Ying Qian,
  • Xuemei Li,
  • Yutao Chen,
  • Zihe Rao

DOI
https://doi.org/10.1038/s41467-021-24458-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Junin virus (JUNV) causes Argentine hemorrhagic fever and encodes the large protein (L) of the RNA dependent RNA polymerase (RdRp) and its regulator, the matrix zinc-binding protein (Z). Here, the authors present the 3.54 Å cryo-EM structure of the complex of JUNV L with Z, and they propose a model of how JUNV L is regulated by Z during the viral life cycle and RNA synthesis.