Nature Communications (Oct 2018)
Generation of orthotopically functional salivary gland from embryonic stem cells
- Junichi Tanaka,
- Miho Ogawa,
- Hironori Hojo,
- Yusuke Kawashima,
- Yo Mabuchi,
- Kenji Hata,
- Shiro Nakamura,
- Rika Yasuhara,
- Koki Takamatsu,
- Tarou Irié,
- Toshiyuki Fukada,
- Takayoshi Sakai,
- Tomio Inoue,
- Riko Nishimura,
- Osamu Ohara,
- Ichiro Saito,
- Shinsuke Ohba,
- Takashi Tsuji,
- Kenji Mishima
Affiliations
- Junichi Tanaka
- Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University
- Miho Ogawa
- Laboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR)
- Hironori Hojo
- Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo
- Yusuke Kawashima
- Laboratory for Integrative Genomics, RIKEN IMS
- Yo Mabuchi
- Department of Biochemistry and Biophysics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University
- Kenji Hata
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Shiro Nakamura
- Department of Oral Physiology, School of Dentistry, Showa University
- Rika Yasuhara
- Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University
- Koki Takamatsu
- Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
- Tarou Irié
- Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University
- Toshiyuki Fukada
- Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University
- Takayoshi Sakai
- Department of Oral-Facial Disorders, Osaka University Graduate School of Dentistry
- Tomio Inoue
- Department of Oral Physiology, School of Dentistry, Showa University
- Riko Nishimura
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Osamu Ohara
- Laboratory for Integrative Genomics, RIKEN IMS
- Ichiro Saito
- Department of Pathology, Tsurumi University School of Dental Medicine
- Shinsuke Ohba
- Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo
- Takashi Tsuji
- Laboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR)
- Kenji Mishima
- Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University
- DOI
- https://doi.org/10.1038/s41467-018-06469-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Functional salivary glands have not been generated from embryonic stem cells (mESCs) to date. Here the authors demonstrate directed in vitro differentiation of mESCs to oral ectoderm and salivary gland rudiments that form mature, functional salivary glands after orthotopic transplantation.
