ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation

Jessica Elmore; Chavez Carter; Amie Redko; Nicholas Koylass; Amelia Bennett; Max Mead; Marinel Ocasio-Rivera; Weishan Huang; Ankur Singh; Avery August

doi:10.1038/s42003-022-03109-1

Communications Biology (Feb 2022)

ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation

Jessica Elmore,
Chavez Carter,
Amie Redko,
Nicholas Koylass,
Amelia Bennett,
Max Mead,
Marinel Ocasio-Rivera,
Weishan Huang,
Ankur Singh,
Avery August

Affiliations

Jessica Elmore: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Chavez Carter: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Amie Redko: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Nicholas Koylass: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Amelia Bennett: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Max Mead: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Marinel Ocasio-Rivera: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Weishan Huang: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University
Ankur Singh: Nancy E & Peter C Meinig School of Biomedical Engineering and Department of Mechanical & Aerospace Engineering, Cornell University
Avery August: Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe-Interactions and Disease, Cornell University

DOI: https://doi.org/10.1038/s42003-022-03109-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

Read online

The kinase Itk is normally required for differentiation of IL-17-producing CD4 T-helper (Th)17 cells however, Elmore, Carter et al. now report that Itk can be bypassed during Th17 differentiation in Saccharopolyspora rectivirgula induced hypersensitivity pneumonitis. This study suggests that some inflammatory signals can override normal T cell activation and differentiation pathways.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal