Antibacterial Activity and Aphrodisiac Potential of the Ethanolic Extracts of Fadogia agretis (Sch winffax Hiern) Stem in Male Albino Rats

Abstract

The research is aimed to evaluate the antibacterial activity and aphrodisiac potential of the ethanolic extracts of Fadogia agrestis (rubiaceae) stem in male albino rats. The antibacterial activity of the extracts were tested on four hospital isolates of staphylococcus aureus, Escherichia coli, Pseudomonas specie and Proteus spp at a concentration of 500µg using disc diffusion method. For aphrodisiac test, healthy, white male albino rats (Rattis novergicus) weighing 270 300g aged 5.0 5.5 months and female albino rats weighing 150 180g aged 3.5 5.4 months were used for the study. The male albino rats were orally dosed with 50mg/kg, 100mg/kg and 200mg/kg body weight respectively of the extract at 24hours intervals. Their sexual behaviour was evaluated for 15 minutes each. The plants extract was found to inhibit staphylococcus aureus and Pseudomonas specie. Aphrodisiac effect of the extract resulted in significant increase in mount behaviour. The antibacterial effects suggest their possible use for the treatment of infection that showed in vitro susceptibility. Also, the increase in the mounting behavior may be responsible for the aphrodisiac effect.

Keywords

• Aphrodisiac potential
• ethanolic extracts
• fadogia agrestis
• albino rats