A Combined Risk Score Model to Assess Prognostic Value in Patients with Soft Tissue Sarcomas

Zihua Li; Zhengwei Duan; Keyao Jia; Yiwen Yao; Kaiyuan Liu; Yue Qiao; Qiuming Gao; Yunfeng Yang; Guodong Li; Anquan Shang

doi:10.3390/cells11244077

Cells (Dec 2022)

A Combined Risk Score Model to Assess Prognostic Value in Patients with Soft Tissue Sarcomas

Zihua Li,
Zhengwei Duan,
Keyao Jia,
Yiwen Yao,
Kaiyuan Liu,
Yue Qiao,
Qiuming Gao,
Yunfeng Yang,
Guodong Li,
Anquan Shang

Affiliations

Zihua Li: Department of Laboratory Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China
Zhengwei Duan: Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Keyao Jia: The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
Yiwen Yao: Department of Internal Medicine V-Pulmonology, Allergology, and Respiratory Intensive Care Medicine, Saarland University Hospital, 66424 Homburg, Germany
Kaiyuan Liu: Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Yue Qiao: Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Qiuming Gao: Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Yunfeng Yang: Department of Orthopedics, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China
Guodong Li: Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Anquan Shang: Department of Laboratory Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China

DOI: https://doi.org/10.3390/cells11244077
Journal volume & issue: Vol. 11, no. 24
p. 4077

Abstract

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A study by Tsvetkov et al. recently published a proposed novel form of copper-induced cell death in Science; however, few studies have looked into the possible mechanism in soft tissue sarcoma (STS). Herein, this study sought to investigate the function of cuproptosis-related genes (CRGs) in the development of tumor-associated immune cells and the prognosis of sarcoma. Herein, this study aimed to explore the role of cuproptosis-related genes (CRGs) in the development, tumor-associated immune cells, and the prognosis of sarcoma. Methods: The prognostic model was established via the least absolute shrinkage and selection operator (LASSO) algorithm as well as multivariate Cox regression analysis. The stromal scores, immune scores, ESTIMA scores, and tumor purity of sarcoma patients were evaluated by the ESTIMATE algorithm. Functional analyses were performed to investigate the underlying mechanisms of immune cell infiltration and the prognosis of CRGs in sarcoma. Results: Two molecular subgroups with different CRG expression patterns were recognized, which showed that patients with a higher immune score and more active immune status were prone to have better prognostic survival. Moreover, GO and KEGG analyses showed that these differentially expressed CRGs were mainly enriched in metabolic/ions-related signaling pathways, indicating that CRGs may have impacts on the immune cell infiltration and prognosis of sarcoma via regulating the bioprocess of mitochondria and consequently affecting the immune microenvironment. The expression levels of CRGs were closely correlated to the immunity condition and prognostic survival of sarcoma patients. Conclusions: The interaction between cuproptosis and immunity in sarcoma may provide a novel insight into the study of molecular mechanisms and candidate biomarkers for the prognosis, resulting in effective treatments for sarcoma patients.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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