مجلة علوم ذي قار (Apr 2019)
Evaluation of Bone Resorption in Type I diabetes Mellitus Patients by Measuring Urinary Total Deoxypyridinoline ( U. DPD) as a Biomarker of Bone Resorption
Abstract
Background: Diabetes mellitus is a common disease in most parts of the world, the metabolic abnormalities of diabetes potentially affect bone metabolism, structure, mineral density, and bone resorption, as part of physiological bone turnover. Aim: This study aimed to estimate urinary total deoxypyridinoline as a biomarker of mature bone collagen degradation and bone resorption in type I diabetes mellitus patients and evaluate its relationship with fasting blood sugar, serum bone minerals profile and the duration of disease and also to investigate the degree of severity of bone resorption and the probability of fracture risk. Patients and methods:165patients with type I diabetes mellitus from Diabetes mellitus and Endocrine Disease Centre at AL -Nasiriyah city in Thi-Qar province, Iraq were studied.100 (60.6%) were female and 65(39.4%) were male, age was between(25-65) year, mean44.27
