Meta-analysis of diagnostic value of OCTA for choroidal neovascularization of wet age-related macular degeneration

Abstract

AIM: To evaluate the diagnostic value of optical coherence tomography angiography(OCTA)in detecting the choroidal neovascularization(CNV)of wet age-related macular degeneration(wARMD).METHODS: PubMed, Embase, Web of science, Cochrane library, CNKI, Wanfang, CBM and VIP databases were searched from inception to October 27, 2020 in diagnosing CNV of wARMD by OCTA. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies by QUADAS-2 standard. Meta-analysis was performed by Meta-Disc 1.4 and Stata 16.0 softwares.RESULTS: A total of 11 studies involving 995 eyes were included. The results of Meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic ratio, the AUC of sROC and the positive post-test probability were 0.88 [95%CI (0.83, 0.92)], 0.95 [95%CI (0.85, 0.99)], 18.45 [95%CI (5.36, 63.52)], 0.12 [95%CI (0.08, 0.18)], 152.73 [95%CI (36.39, 641.05)], 0.95 [95%CI (0.92, 0.96)] and 0.96 respectively.CONCLUSION: OCTA has significant diagnostic value for CNV of wARMD, especially for patients with early wARMD.

Keywords

• optical coherence tomography angiography
• wet age-related macular degeneration
• choroidal neovascularization
• diagnosis
• meta-analysis