Nature Communications (May 2017)
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
- Philip Hasel,
- Owen Dando,
- Zoeb Jiwaji,
- Paul Baxter,
- Alison C. Todd,
- Samuel Heron,
- Nóra M. Márkus,
- Jamie McQueen,
- David W. Hampton,
- Megan Torvell,
- Sachin S. Tiwari,
- Sean McKay,
- Abel Eraso-Pichot,
- Antonio Zorzano,
- Roser Masgrau,
- Elena Galea,
- Siddharthan Chandran,
- David J. A. Wyllie,
- T. Ian Simpson,
- Giles E. Hardingham
Affiliations
- Philip Hasel
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- Owen Dando
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- Zoeb Jiwaji
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- Paul Baxter
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- Alison C. Todd
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- Samuel Heron
- School of Informatics, University of Edinburgh
- Nóra M. Márkus
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- Jamie McQueen
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- David W. Hampton
- MRC Centre for Regenerative Medicine, University of Edinburgh
- Megan Torvell
- MRC Centre for Regenerative Medicine, University of Edinburgh
- Sachin S. Tiwari
- MRC Centre for Regenerative Medicine, University of Edinburgh
- Sean McKay
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- Abel Eraso-Pichot
- Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Medicina, Edifici M, Universitat Autònoma de Barcelona
- Antonio Zorzano
- Institute for Research in Biomedicine
- Roser Masgrau
- Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Medicina, Edifici M, Universitat Autònoma de Barcelona
- Elena Galea
- Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Medicina, Edifici M, Universitat Autònoma de Barcelona
- Siddharthan Chandran
- MRC Centre for Regenerative Medicine, University of Edinburgh
- David J. A. Wyllie
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- T. Ian Simpson
- School of Informatics, University of Edinburgh
- Giles E. Hardingham
- Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh
- DOI
- https://doi.org/10.1038/ncomms15132
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
How neurons and neuronal activity regulate astrocyte functions is poorly understood. Haselet al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interestingly, many of these genes are dysregulated in neurodegeneration.
