SAM-VI riboswitch structure and signature for ligand discrimination

Aiai Sun; Catherina Gasser; Fudong Li; Hao Chen; Stefan Mair; Olga Krasheninina; Ronald Micura; Aiming Ren

doi:10.1038/s41467-019-13600-9

Nature Communications (Dec 2019)

SAM-VI riboswitch structure and signature for ligand discrimination

Aiai Sun,
Catherina Gasser,
Fudong Li,
Hao Chen,
Stefan Mair,
Olga Krasheninina,
Ronald Micura,
Aiming Ren

Affiliations

Aiai Sun: Life Sciences Institute, Zhejiang University
Catherina Gasser: Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, Leopold Franzens University
Fudong Li: National Science Center for Physical Sciences at Microscale Division of Molecular & Cell Biophysics and School of Life Sciences, University of Science and Technology of China
Hao Chen: Life Sciences Institute, Zhejiang University
Stefan Mair: Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, Leopold Franzens University
Olga Krasheninina: Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, Leopold Franzens University
Ronald Micura: Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, Leopold Franzens University
Aiming Ren: Life Sciences Institute, Zhejiang University

DOI: https://doi.org/10.1038/s41467-019-13600-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Riboswitches are conserved RNA domains located in the non-coding region of mRNA that recognize cellular metabolites and, in turn, regulate gene expression. Here the authors report the structure of the recently identified SAM-VI riboswitch and provide insight into its mechanism of ligand discrimination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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