Histological and Nanomechanical Properties of a New Nanometric Hydroxiapatite Implant Surface. An In Vivo Study in Diabetic Rats

Paula G. F. P. Oliveira; Paulo G. Coelho; Edmara T. P. Bergamo; Lukasz Witek; Cristine A. Borges; Fábio B. Bezerra; Arthur B. Novaes; Sergio L. S. Souza

doi:10.3390/ma13245693

Materials (Dec 2020)

Histological and Nanomechanical Properties of a New Nanometric Hydroxiapatite Implant Surface. An In Vivo Study in Diabetic Rats

Paula G. F. P. Oliveira,
Paulo G. Coelho,
Edmara T. P. Bergamo,
Lukasz Witek,
Cristine A. Borges,
Fábio B. Bezerra,
Arthur B. Novaes,
Sergio L. S. Souza

Affiliations

Paula G. F. P. Oliveira: Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Paulo G. Coelho: Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, NY 10010, USA
Edmara T. P. Bergamo: Department of Prosthodontic and Periodontology, Bauru School of Dentistry, University of Sao Paulo, Av. Octavio Pinheiro Brisolla9-75, Bauru, SP 17012-901, Brazil
Lukasz Witek: Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY 10010, USA
Cristine A. Borges: Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Fábio B. Bezerra: Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Arthur B. Novaes: Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Sergio L. S. Souza: Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil

DOI: https://doi.org/10.3390/ma13245693
Journal volume & issue: Vol. 13, no. 24
p. 5693

Abstract

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Implant therapy is a predictable treatment to replace missing teeth. However, the osseointegration process may be negatively influenced by systemic conditions, such as diabetes mellitus (DM). Microtopography and implant surface developments are strategies associated to better bone repair. This study aimed to evaluate, in healthy and diabetic rats, histomorphometric (bone to implant contact = %BIC; and bone area fraction occupancy = %BAFO) and nanomechanical (elastic modulus = EM; and hardness = H) bone parameters, in response to a nanometric hydroxyapatite implant surface. Mini implants (machined = MAC; double acid etched = DAE, and with addition of nano-hydroxyapatite = NANO) were installed in tibias of healthy and diabetic rats. The animals were euthanized at 7 and 30 days. NANO surface presented higher %BIC and %BAFO when compared to MAC and DAE (data evaluated as a function of implant surface). NANO surface presented higher %BIC and %BAFO, with statistically significant differences (data as a function of time and implant surface). NANO surface depicted higher EM and H values, when compared to machined and DAE surfaces (data as a function of time and implant surface). Nano-hydroxyapatite coated implants presented promising biomechanical results and could be an important tool to compensate impaired bone healing reported in diabetics.

Published in Materials

ISSN: 1996-1944 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering; Technology: Engineering (General). Civil engineering (General); Science: Natural history (General): Microscopy; Science: Physics: Descriptive and experimental mechanics
Website: http://www.mdpi.com/journal/materials/

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