A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors

Tingting Wang; Dangge Wang; Haijun Yu; Bing Feng; Fangyuan Zhou; Hanwu Zhang; Lei Zhou; Shi Jiao; Yaping Li

doi:10.1038/s41467-018-03915-4

Nature Communications (Apr 2018)

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors

Tingting Wang,
Dangge Wang,
Haijun Yu,
Bing Feng,
Fangyuan Zhou,
Hanwu Zhang,
Lei Zhou,
Shi Jiao,
Yaping Li

Affiliations

Tingting Wang: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Dangge Wang: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Haijun Yu: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Bing Feng: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Fangyuan Zhou: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hanwu Zhang: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Lei Zhou: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Shi Jiao: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Yaping Li: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-018-03915-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Cancer vaccines represent a promising personalized therapeutic approach to treating cancer. Here, the authors report the efficacy in a metastatic model of a cancer vaccine-mediated postoperative immunotherapy, based on the coencapsulation of the JQ1 and a photosensitizer ICG together with inactivated tumor cells into a hydrogel matrix.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal