Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

Xiaogang Wang; Christopher D. Thompson; Christopher Weidenmaier; Jean C. Lee

doi:10.1038/s41467-018-03847-z

Nature Communications (Apr 2018)

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

Xiaogang Wang,
Christopher D. Thompson,
Christopher Weidenmaier,
Jean C. Lee

Affiliations

Xiaogang Wang: Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Christopher D. Thompson: Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Christopher Weidenmaier: Interfaculty Institute for Microbiology and Infection Medicine, University of Tuebingen
Jean C. Lee: Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-03847-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

Extracellular vesicles (EVs) influence host-pathogen interactions, but EV biogenesis in gram-positive bacteria remains elusive. Here authors characterize EVs from Staphylococcus aureus and show that phenol-soluble modulins and autolysins promote EV biogenesis by disrupting the membrane and cell wall.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal