Antidepressant Prophylaxis Reduces Depression Risk but Does Not Improve Sustained Virological Response in Hepatitis C Patients Receiving Interferon Without Depression at Baseline: A Systematic Review and Meta-Analysis

Awad Al-Omari; Juthaporn Cowan; Lucy Turner; Curtis Cooper

doi:10.1155/2013/832689

Canadian Journal of Gastroenterology (Jan 2013)

Antidepressant Prophylaxis Reduces Depression Risk but Does Not Improve Sustained Virological Response in Hepatitis C Patients Receiving Interferon Without Depression at Baseline: A Systematic Review and Meta-Analysis

Awad Al-Omari,
Juthaporn Cowan,
Lucy Turner,
Curtis Cooper

Affiliations

Awad Al-Omari: University of Ottawa, Division of Infectious Diseases, Ottawa, Ontario, Canada
Juthaporn Cowan: University of Ottawa, Division of Infectious Diseases, Ottawa, Ontario, Canada
Lucy Turner: Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Curtis Cooper: University of Ottawa, Division of Infectious Diseases, Ottawa, Ontario, Canada

DOI: https://doi.org/10.1155/2013/832689
Journal volume & issue: Vol. 27, no. 10
pp. 575 – 581

Abstract

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BACKGROUND: Depression complicates interferon-based hepatitis C virus (HCV) antiviral therapy in 10% to 40% of cases, and diminishes patient well-being and ability to complete a full course of therapy. As a consequence, the likelihood of achieving a sustained virological response (SVR [ie, permanent viral eradication]) is reduced.

Published in Canadian Journal of Gastroenterology

ISSN: 0835-7900 (Print); 1916-7237 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://onlinelibrary.wiley.com/journal/1720

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