Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation

Teng Wang; Kongxi Zhu; Weihua Yu; Lei Peng; Hongjuan Wang; Qiong Wu

Stem Cell Research (Sep 2023)

Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation

Teng Wang,
Kongxi Zhu,
Weihua Yu,
Lei Peng,
Hongjuan Wang,
Qiong Wu

Affiliations

Teng Wang: Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China
Kongxi Zhu: Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China
Weihua Yu: Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China
Lei Peng: Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China
Hongjuan Wang: Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China
Qiong Wu: Corresponding author.; Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China

Journal volume & issue: Vol. 71
p. 103152

Abstract

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We established an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome, carrying heterozygous c.290 + 1G > A mutation in STK11 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expressed pluripotency markers, could differentiate into cells of three germ layers in vitro, and displayed a normal karyotype.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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